Path of Exile 2: The Slithering Dead Quest Guide
This guide details the "Slithering Dead" side quest in Path of Exile 2, focusing on its walkthrough and reward choices. The quest involves helping Servi uncover the fate of her son, Apus.
The Slithering Dead Quest Walkthrough:

To begin, locate the Venom Crypts entrance within the Act 3 (and Act 3 Cruel) Jungle Ruins map. It's situated near the Waypoint. The Venom Crypts are optional; you can revisit them later if missed.
Explore the Venom Crypts until you find a corpse in the Den of the Serpent Priestess (location varies per map).

Interact with the corpse to obtain Corpse-Snake Venom. Return to Servi in the Ziggurat Encampment to complete the quest.
Choosing Your Venom Draught Reward:

The Slithering Dead is repeatable (Act 3 and Act 3 Cruel). Rewards differ each time, and the choice is permanent.
Act 3 Rewards:
- Venom Draught of Stone: 25% increased Stun Threshold.
- Venom Draught of the Veil: 30% increased Elemental Ailment Threshold.
- Venom Draught of Clarity: 25% increased Mana Regeneration Rate.
Generally, the Venom Draught of Clarity is the most versatile choice, particularly beneficial for mana-hungry melee builds. The Venom Draught of the Veil is a strong alternative for builds less reliant on mana. The Venom Draught of Stone is the least desirable unless specifically needed to mitigate stun effects.
Act 3 Cruel (Act 6) Rewards:
- Venom Draught of the Lost: +10% to Chaos Resistance.
- Venom Draught of the Sky: +5 to All Attributes.
- Venom Draught of the Marshes: 15% Reduced Slowing Potency of Debuffs.
Here, the Venom Draught of the Lost (+10% Chaos Resistance) is usually the optimal choice due to the rarity of Chaos Resistance on gear. Only builds utilizing Chaos Inoculation might prefer the Venom Draught of the Sky for its attribute boost.
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