In Once Human, your gear and weapon choices are the foundation of your combat effectiveness. Whether you're clearing corrupted enemies in PvE or engaging in intense PvP battles, a well-optimized build can mean the difference between victory and respawning.

This guide presents four of the most powerful builds currently available in Once Human, each featuring detailed recommendations on weapons, gear mods, synergy effects, and ideal playstyle strategies. From area-of-effect (AoE) clearing setups to damage-over-time (DoT) builds and critical burst loadouts, every configuration has been tested for efficiency in both solo and group scenarios.

New players should also check out our Beginner’s Guide for Once Human for an essential introduction to the game's core mechanics and systems.

Final Tips for Optimizing Your Build

• Sync weapon effects and mods: Select gear that amplifies your weapon’s primary elemental or status effects for maximum impact.
• Keep upgrading: Gear rarity and enhancement levels significantly boost performance—always use the latest and highest-tier equipment available.
• Craft backup loadouts: Prepare alternative builds based on different elements to counter enemy resistances or adapt to PvP situations.

Each build in Once Human performs uniquely depending on the scenario—whether it's taking down bosses, managing large enemy waves, or executing fast takedowns in PvP. Take time to experiment with each setup, adjust your gear mods accordingly, and switch builds as needed based on mission type or enemy composition.

For a seamless and high-performance gaming experience—complete with lag-free aiming, multi-instance support, and smooth inventory control—play Once Human on BlueStacks. Enhance your gameplay further with full keyboard and mouse support, and enjoy consistently stable frame rates.